This volume grew out of a conference at DIMACS 

(Center for Discrete Mathematics & Theoretical Computer Science)

Conference website with full agenda and abstracts of additional talks

This volume expands our imagination 

           as to the types of information

      embedded in genomes

and how that information can be

      organized, integrated and represented.



Effects of Genome Structure and Sequence on Variation and Evolution: 


Table of Contents



Overview of the creative genome: effects of genome structure and sequence on the generation of variation and evolution  
Lynn Helena Caporale

Genome hyperevolution and the success of a parasite
​J. David Barry, James P. J. Hall and Lindsey Plenderleith

The tricky path to recombining X and Y chromosomes in meiosis 
Liisa Kauppi, Maria Jasin and Scott Keeney

Sites of genetic instability in mitosis and cancer 
Anne M. Casper, Danielle M. Rosen and Kaveri D. Rajula

The genome: an isochore ensemble and its evolution 
Giorgio Bernardi

Multiple levels of meaning in DNA sequences, and one more
Edward N. Trifonov, Zeev Volkovich and Zakharia M. Frenkel

Evolution of simple sequence repeat–mediated phase variation in bacterial genomes
Christopher D. Bayliss and Michael E. Palmer

Indirect selection of implicit mutation protocols
David G. King

G4 motifs in human genes 
Nancy Maizels

Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes
Baldomero M. Olivera, Maren Watkins, Pradip Bandyopadhyay, Julita S. Imperial, Edgar P. Heimer de la Cotera,
​ Manuel B.Aguilar, Estuardo López Vera, Gisela P. Concepcion and Arturo Lluisma

Integrons and gene cassettes: hotspots of diversity in bacterial genomes
Ruth M. Hall

Creative deaminases, self-inflicted damage, and genome evolution 
Silvestro G. Conticello

Three-dimensional architecture of the IgH locus facilitates class switch recombination


Amy L. Kenter, Scott Feldman, Robert Wuerffel, Ikbel Achour, Lili Wang and Satyendra Kumar

Preaching about the converted: how meiotic gene conversion influences genomic diversity
Francesca Cole, Scott Keeney and Maria Jasin

Gross chromosomal rearrangement mediated by DNA replication in stressed cells: evidence from Escherichia coli
J.M. Moore, Hallie Wimberly, P.C. Thornton, Susan M. Rosenberg and P.J. Hastings

Implications of genetic heterogeneity in cancer
Michael W. Schmitt, Marc J. Prindle and Lawrence A. Loeb