Molecular Strategies in Biological Evolution


​Lynn Caporale Chance Favors the Prepared Genome

Part I. Structured Pathways for Variation: Evolution as a Biological Function
James Shapiro            Genome System Architecture and Natural Genetic Engineering in Evolution
Werner Arber            Involvement of Gene Products in Bacterial Evolution
Susanna Lewis et al.            Palindromic DNA and Genome Stability
Susanna Lewis             Evolution of Immunoglobulin and T-Cell Receptor Gene Assembly
Ruth Hall et al.            Mobile Gene Cassettes and Integrons in Evolution
Giorgio Bernardi et al.            Evolutionary ​Genomics of Vertebrates and Its Implications

Part II. Modulation of Fidelity and Repair: Fidelity and Flexibility in Evolution

Stephen Benkovic            Introduction and Summary of Discussion
John Drake            The Distribution of Rates of Spontaneous Mutation over Viruses, Prokaryotes and Eukaryotes
. Abram Gabriel and Emilie Mules            Fidelity of Retrotransposon Replication
​ Alan Herbert and Alexander Rich            RNA Processing in Evolution. The Logic of Soft-Wired Genomes
Patricia Foster and William Rosche            Mechanisms of Mutation in Nondividing Cells. Insights from the Study of Adaptive Mutation in E. Coli
Miroslav Radman et al.            Evolution of Evolvability

Part III: Context-Dependent Genetic Alteration: Cell and Sequence Context-Dependent Effects on Genetic Variation 

Lynn Ripley            Predictability of Mutant Sequences. Relationships between Mutational Mechanisms and Mutant Specificity
Richard Sinden et al.            DNA-Directed Mutations. Leading and Lagging Strand Specifity
Larry Simpson and Dmitri Maslov            Evolution of the U-Insertion/Deletion RNA Editing in Mitochondria of Kinetoplastid Protozoa
Amy Kenter and Robert Wuerffel            Immunoglobulin Switch Recombination May Occur by a DNA End-Joining Mechanism

Part IV: New Contents for Functional DNA Sequences: How Do New Functions Evolve? 

John Schimenti et al.            Transgenic and Mutational Analyses of Meiotic Recombination in Mice

Baldomero Olivera            Speciation of Cone Snails and Interspecific Hyperdivergence of Their Venom Peptides. Potential Evolutionary Significance of Introns

Frank Ruddle et al.            Evolution of Chordate Hox Gene Clusters

Monica Riley            Summary 

Part V: Regulation of Genetic Variation

Nina Fedoroff            Transposable Elements As a Molecular Evolutionary Force

Shigeru Iida            Floricultural Traits and Transposable Elements in the Japanese and Common Morning Glories

Susan Rosenberg et al.            Mechanisms of Genome-Wide Hypermutation in Stationary Phase
Evelyn Fox Keller            Summary

Historic Perspectives

Werner Arber Future Directions: Strategies and Perspectives

Maclyn McCarty Further Remarks

​Werner Arber Concluding Remarks 

plus 21 additional articles from the poster session including David Thaler, Laura Landweber,  H. Gotoh, I. Kobayashi, K. Gardiner, Y. Toda, J. Strathern,

Richard Moxon, T. Cebula, D. King, Frances Arnold, H. Ochman

Evolution is a biological process, responsive to the environment, and informed through the experience of generations.

Far from clumsy stumblers into random point mutations, genomes have evolved mechanisms that facilitate their own evolution.

These mechanisms...diversify a genome and increase the probability that its descendants will survive...."

                                   ----Lynn Caporale

Preface to Molecular Strategies in Biological Evolution

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Maclyn McCarty contributed a brief perspective