Table of Contents


Overview of The Implicit Genome
Lynn Helena Caporale
Sequence-Dependent Properties of DNA and their Role in Function
Donald Crothers

Mutation as a Phenotype
Errol C. Friedberg

Repeats and Variation in Pathogen Selection
​ Chris Bayliss & Richard Moxon

Tuning Knobs in the Genome:
Evolution of Simple Sequence Repeats by Indirect Selection
David G. King, Edward N. Trifonov, Yechezkel Kashi

Implicit Information in Eukaryotic Pathogens as the Basis of
​Antigenic Variation
​ J Dave Barry  

​ The role of repeat sequences in bacterial genetic adaptation to stress
Eduardo P. C. Rocha  

​ The Role of Mobile DNA in the Evolution of Prokaryotic Genomes
Garry Myers, Ian Paulsen & Claire Fraser

Eukaryotic Transposable Elements: Teaching Old Genomes New Tricks
​ Susan R. Wessler

Immunoglobulin Recombination Signal Sequences: Somatic and Evolutionary Functions
Ellen Hsu

Somatic Evolution of Antibody Genes
Rupert Beale & Dagmar Iber

Regulated and Unregulated Recombination of G-rich Genomic Regions
Nancy Maizels

The Role of the Genome in the Initiation of Meiotic Recombination
Rhona H. Borts & David T. Kirkpatrick

​ Nuclear Duality and the Genesis of Unusual Genomes in Ciliated Protozoa
Carolyn L. Jahn

Editing Informational Content of Expressed DN Sequences and Their Transcripts 
Harold C. Smith

  Alternative Splicing: One Gene, Many Products
Brenton R. Graveley

Imprinting: The Hidden genome
Alyson Ashe & Emma Whitelaw

Epilogue: An Engineering Perspective: The Implicit Protocols
John Doyle, Marie Csete, and Lynn Caporale
​  
INFORMATION HAS EVOLVED IN GENOMES THAT IS REPRESENTED
NOT ONLY IN LINEAR SEQUENCES,
BUT ALSO IN THE STRUCTURE
OF DNA OR RNA AND IN THE RELATIONSHIPS AMONG SEQUENCES.  

EXAMPLES REVIEWED IN THIS VOLUME, TAKEN FROM A BROAD RANGE OF ORGANISMS FROM BACTERIA TO HUMANS, BOTH EXPAND OUR IMAGINATION AS TO THE NATURE OF INFORMATION ENCODED WITHIN GENOMES AND DEEPEN OUR APPRECIATION OF THE POWER OF NATURAL SELECTION, THROUGH WHICH THIS INFORMATION, IN ITS VARIOUS FORMS, HAS EMERGED.